Manchester United vs Southampton LIVE: Premier League result, final score and reaction

Ten Hag makes two changes to the United side which started Thursday's win over Betis – as well as last week's rout at Liverpool. Fred and Dalot are the men to make way, with Wan-Bissaka coming in for his 100th Premier League appearance for United at right-back. The other player brought in is Sancho, with Fernandes likely to occupy a deeper position alongside Casemiro.

SOUTHAMPTON SUBS: Alex McCarthy, Duje Caleta-Car, Adam Armstrong, Paul Onuachu, Stuart Armstrong, Sekou Mara, Mohammed Salisu, Mohamed Elyounoussi, Ibrahima Diallo.

SOUTHAMPTON (4-2-3-1): Gavin Bazunu; Kyle Walker-Peters, Jan Bednarek, Armel Bella-Kotchap, Romain Perraud; Romeo Lavia, James Ward-Prowse; Kamaldeen Sulemana, Carlos Alcaraz, Theo Walcott; Che Adams.

MANCHESTER UNITED SUBS: Tom Heaton, Harry Maguire, Tyrell Malacia, Fred, Diogo Dalot, Facundo Pellistri, Scott McTominay, Alejandro Garnacho, Kobbie Mainoo.

MANCHESTER UNITED (4-2-3-1): David de Gea; Aaron Wan-Bissaka, Raphael Varane, Lisandro Martinez, Luke Shaw; Bruno Fernandes, Casemiro; Antony, Wout Weghorst, Jadon Sancho; Marcus Rashford.

Southampton, meanwhile, are in desperate need of points after seeing several fellow relegation candidates earn results on Saturday. Ruben Selles' team are bottom and three points behind 17th-placed Bournemouth after the Cherries' shock victory over Liverpool. Saints did claim a vital 1-0 win over Leicester City last time out – their second in three league games under Selles – so perhaps they should not be written off just yet.

United responded to their humiliating 7-0 defeat at Liverpool in fine fashion on Thursday, hammering Real Betis 4-1 to claim the advantage in their Europa League last-16 tie. Erik ten Hag's men turn their attentions back to league action here, knowing a win over Saints would take them four points clear of fourth-placed Tottenham – and seven ahead of fifth-placed Liverpool.