Shay Given will not make his first Premier League appearance of the season with Mark Hughes instead handing a league debut to Jakob Haugaard.
After No 1 Jack Butland was injured while on England duty, 39-year-old Given was in the frame to play.
However, Hughes will instead play the 23-year-old Dane, his first Premier League game since joining from FC Midtjylland last summer.
Hughes has made two other changes to his side, Bojan coming in for Jon Walters - who was also injured while on Republic of Ireland duty - and and Erik Pieters coming in for Marc Muniesa at left-back.
Swansea City boss Francesco Guidolin has made three changes to his team.
Kyle Naughton comes in for youngster Stephen Kingsley at left-back, Leon Britton for Ki Seung-yeung in midfield and Wayne Roytledge for Modou Barrow on the wing.
TEAM NEWS:
Stoke City: Haugaard, Bardsley, Cameron, Wollscheid, Pieters, Whelan, Imbula, Arnautovic, Bojan, Afelay, Joselu
Subs: Given, Muniesa, Ireland, Adam, Diouf, Crouch, Choulay
Swansea City: Fabianski, Rangel, Fernandez, Williams, Naughton, Britton, Fer, Cork, Sigurdsson, Routledge, Gomis.
Subs: Nordfeldt, Amat, Taylor, Ki Sung-Yueng, Montero, Emnes, Paloschi.
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