Major US hospitals launch not-for-profit drug company to battle pharmaceutical corporations

A group of major American hospitals, battered by price spikes on old drugs and long-lasting shortages of critical medicines, has launched a mission-driven, not-for-profit generic drug company, Civica Rx, to take some control over the drug supply.

Backed by seven large health systems and three philanthropic groups, the new venture will be led by an industry insider who refuses to draw a salary. The company will focus initially on establishing price transparency and stable supplies for 14 generic drugs used in hospitals, without pressure from shareholders to issue dividends or push a stock price higher.

"We're trying to do the right thing - create a first-of-its-kind societal asset with one mission: to make sure essential generic medicines are affordable and available to everyone," said Dan Liljenquist, chair of Civica Rx and chief strategy officer at Intermountain Healthcare in Utah.

The consortium, which includes health systems such as the Mayo Clinic and HCA Healthcare, collectively represents about 500 hospitals. Mr Liljenquist said that the initial governing members have already committed $100 million to the effort. The business model will ultimately rely on the long-term contracts that member health-care organisations agree to - a commitment to buy a fixed portion of their drug volume from Civica.

While Civica did not disclose which drugs it is focusing on for competitive reasons, Elie Bahou, chief pharmacy officer of Providence St Joseph Health, a 51-hospital system spread across seven states and one of the members of the consortium, said the criteria include drugs that underwent price increases of 50 per cent or more between 2014 and 2016 and essential medicines that were on national shortage lists.

A 2016 survey commissioned by hospital lobbying groups found that a third of hospital administrators reported that higher drug prices had a "severe" effect on their ability to manage their budgets.

Several hospital leaders said shortages and price spikes on old drugs are managed on a near-daily basis. The cost is not just the price of a drug, but the clinical and staff time spent tracking the supply, looking for alternatives and changing protocols. For hospital systems that are in multiple states, the shortage problems are often hyperlocal, too - in one state, morphine might be available while fentanyl is in shortage, while in another, the reverse could be true. So the one solution may not even work system-wide.

"There's a whiteboard at every one of our pharmacies, and there are 10 to 20 drugs on the whiteboard and a number - that's the supply they have on hand. And depending on what that number is, they'll strategise: What are we going to do," said Bob Ripley, chief pharmacy officer of Trinity Health, one of the health systems in the consortium.

Civica Rx's first drug could hit the market next year and the company has committed to a transparent pricing model, without secret rebates that are common throughout the pharmaceutical industry.

Martin VanTrieste, chief executive of Civica, worked in the traditional pharmaceutical industry for decades - most recently at biotech giant Amgen - and said that he came out of retirement to take on the role with two requirements: He would work without pay and the company had to remain focused on patients. The question of how big the company might grow, he said, depends on how the market reacts.

"We want the marketplace to take care of itself and work, so if the entrance of Civica with 14 drugs - and the threat we can do more - pretty quickly, makes the marketplace work better, we probably don't grow much bigger than that," Mr VanTrieste said. "But if the marketplace is broken and can't be fixed by adding just 14 drugs," the company could expand much more.

There are risks to the idea. Civica's leaders have discussed the possibility that other companies that make the generic drugs will temporarily cut their prices in an effort to maintain market share. But Civica leaders say the model of guaranteeing a steady supply at a fair, transparent price will be attractive to hospitals. Since the effort was first outlined in January, health organisations that represent a third of the nation's hospitals have expressed interest.

"The risk of doing nothing is that we'll continue with the same price escalations and shortages we've had," said Amy Compton-Phillips, chief clinical officer of Providence St Joseph Health. "The risk of doing nothing to me seems higher than actually trying creative solutions to solve the problem."

The Washington Post