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Alcoholics to be given ketamine to see if it reduces alcohol use

Researchers will look at whether the ketamine and therapy package reduces harmful drinking.

Lucas Cumiskey
Monday 12 December 2022 19:01 EST
Researchers will look at whether the ketamine and therapy package reduces harmful drinking (PA)
Researchers will look at whether the ketamine and therapy package reduces harmful drinking (PA) (PA Wire)

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Alcoholics will be given ketamine-assisted therapy as part of a £2.4 million phase three trial to see if it helps them stay off alcohol for longer.

The University of Exeter-led trial, funded by the National Institute for Health and Care Research (NIHR), will be delivered across seven NHS sites across the UK.

NIHR is funded by the Department of Health and Social Care and it funds health and social care research in the UK.

It comes after a phase two trial showed ketamine and therapy treatment was safe and tolerable for heavy drinkers.

The earlier study found that participants who had ketamine combined with therapy stayed completely sober, representing 86% abstinence in the six month follow-up.

The Ketamine for Reduction of Alcohol Relapse (Kare) trial will now move to the next step of drug development, with the aim of rolling it out into the NHS if it proves effective.

Ketamine is a licensed medical drug, widely used as an anaesthetic and in pain relief.

It is also used as a recreational drug and is classified as a Class B banned substance by the Home Office.

The trial will recruit 280 people with alcohol problems who will be randomly split into two groups.

Half will be given ketamine at the dose used in the first clinical trial with psychological therapy.

Alcohol-related harm is estimated to cost the NHS around £3.5 billion each year, and wider UK society around £40 billion

Professor Celia Morgan, from the University of Exeter

The other half will be given a very low dose of ketamine and a seven-session education package about the harmful effects of alcohol.

Researchers will look at whether the ketamine and therapy package reduces harmful drinking.

Trial lead Professor Celia Morgan, from the University of Exeter, said: “More than two million UK adults have serious alcohol problems, yet only one in five of those get treatment.

“Three out of four people who quit alcohol will be back drinking heavily after a year.

“Alcohol-related harm is estimated to cost the NHS around £3.5 billion each year, and wider UK society around £40 billion.

If this trial establishes that ketamine and therapy works, we hope we can begin to see it used in NHS settings

Professor Celia Morgan, from the University of Exeter

“Alcohol problems affect not only the individual but families, friends and communities, and related deaths have increased still further since the pandemic.

“We urgently need new treatments.

“If this trial establishes that ketamine and therapy works, we hope we can begin to see it used in NHS settings.”

The new trial will recruit participants across Imperial College London; Oxford Health NHS Trust; Greater Manchester Mental Health NHS Trust; Northern, Eastern, and Western Devon CCG; South London and Maudsley NHS Foundation Trust; the Exeter Clinical Trials Unit; Mersey Care NHS Trust; University College London Hospitals NHS Foundation Trust; NHS Forth Valley; Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust.

Recruitment will start mid-way through 2023.

Awakn Life Sciences, a biotech company that specialises in researching and developing therapeutics to treat addiction, will provide additional funding.

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