Row over breast cancer trial
Your support helps us to tell the story
From reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it's investigating the financials of Elon Musk's pro-Trump PAC or producing our latest documentary, 'The A Word', which shines a light on the American women fighting for reproductive rights, we know how important it is to parse out the facts from the messaging.
At such a critical moment in US history, we need reporters on the ground. Your donation allows us to keep sending journalists to speak to both sides of the story.
The Independent is trusted by Americans across the entire political spectrum. And unlike many other quality news outlets, we choose not to lock Americans out of our reporting and analysis with paywalls. We believe quality journalism should be available to everyone, paid for by those who can afford it.
Your support makes all the difference.BRITISH cancer experts yesterday accused their counterparts in the United States of jeopardising key research on the breast cancer drug tamoxifen by releasing data prematurely.
They said that Britain's only clinical trial aimed at preventing breast cancer could now be in danger of collapse as doctors fear women at high risk will "inundate" clinics in order to be prescribed tamoxifen, or leave the trial altogether.
In a five-year study by the US National Cancer Institute, tamoxifen was found to almost halve cancer rates among women at high risk of having the disease. The institute notified the 13,000 women in the trial so that those who had been taking the placebo could consider starting tamoxifen therapy.
But the British experts said that the US results had not been released properly and had not as yet been peer-reviewed. They added that the decision to "unblind" the study - that is tell women whether they were on the placebo drug or tamoxifen - meant that results on the long-term effects of taking the drug were "confounded".
As a result, the future of the British trial, part of the International Breast Cancer Intervention Study (IBIS) is now in question, oncologists said yesterday. Professor Tony Howell, of the Christie Hospital, Manchester, co-chairman of IBIS, said: "Our emphasis is to try and get long-term data from [IBIS] so we will know whether it's good for women in the long term. Unfortunately the Americans will not be able to do that now, because they are prematurely stopping their trial."
Professor Michael Baum, professor of surgery at University College London, said: "I don't know what I am going to tell my patients, but I think they should have an informed choice."
Leading article, page 18
Join our commenting forum
Join thought-provoking conversations, follow other Independent readers and see their replies
Comments