Antibiotics increase chances of mild flu turning deadly, study suggests
The findings show that animals are less likely to survive as the treatment can wipe out gut bacteria
Your support helps us to tell the story
From reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it's investigating the financials of Elon Musk's pro-Trump PAC or producing our latest documentary, 'The A Word', which shines a light on the American women fighting for reproductive rights, we know how important it is to parse out the facts from the messaging.
At such a critical moment in US history, we need reporters on the ground. Your donation allows us to keep sending journalists to speak to both sides of the story.
The Independent is trusted by Americans across the entire political spectrum. And unlike many other quality news outlets, we choose not to lock Americans out of our reporting and analysis with paywalls. We believe quality journalism should be available to everyone, paid for by those who can afford it.
Your support makes all the difference.Taking antibiotics at the first signs of illness can increase the chances of mild flu turning deadly, a study has shown.
Bacteria in the gut helps prime the immune system to respond to early signs of viruses invading the lungs and suppress the infection, researchers, led by the Francis Crick Institute in London, found.
Tests in mice infected with influenza found they were three times more likely to die after receiving a course of antibiotics as those left to fight the illness alone.
This was “further evidence that antibiotics should not be taken or prescribed lightly” the researchers said.
Health systems around the world are grappling with the rising threat of antibiotic resistance which could return medicine to the “dark ages” and make simple cuts deadly.
Inappropriate use of the drugs, often given for viral infections where they are ineffective or to help fatten up livestock, wipes out beneficial and harmful bacteria and increases the pressure for the bugs to adapt.
This is leading to untreatable infections like “super-gonorrhoea” which can even withstand drugs held back as a last resort.
Gut bacteria ensure that antiviral genes in the lung lining stay active and are ready to react as a first line of defence when flu emerges, the researchers found.
The cells lining the lung "are the only place that the virus can multiply, so they are the key battleground in the fight against flu,” they reported in the journal, Cell Reports.
They added: “Gut bacteria send a signal that keeps the cells lining the lung prepared, preventing the virus from multiplying so quickly.”
A third of the mice survived when given antibiotics before becoming infected, compared to 80 per cent who survived without the drugs, in the study.
The virus lies dormant before symptoms emerge and two days after infection, mice which had received antibiotics had five times more virus in their lungs.
This means that when the immune system does identify the threat its response has to be much stronger.
This immune response can be just as harmful as the infection, as happens with sepsis which can cause organ failure, lost limbs and death.
“We found that antibiotics can wipe out early flu resistance, adding further evidence that they should not be taken or prescribed lightly,” says the study’s lead researcher, Dr Andreas Wack. “Inappropriate use not only promotes antibiotic resistance and kills helpful gut bacteria, but may also leave us more vulnerable to viruses.”
He said the findings were “not only relevant in humans” as it could show similar risks for livestock herds treated with antibiotics.
Join our commenting forum
Join thought-provoking conversations, follow other Independent readers and see their replies
Comments